Most synthetic cannabinoids are agonists from the cannabinoid receptors. They are already intended to be comparable to THC,[nine] the all-natural cannabinoid with the strongest binding affinity for the CB1 receptor, which happens to be associated with the psychoactive effects or "high" of cannabis.[10] These synthetic analogs typically have larger binding affinity and bigger potency to your CB1 receptors.
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The explanation for that adjust on the quinolone substructure is unknown, but it might happen to be observed to become a suitable alternative with the naphthoyl moiety which is at present controlled by US scheduling regulations.[eighty three]
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